Sleep is essential for the optimal development and overall health of children and adolescents. In addition, consistent nighttime sleep is important for brain plasticity and enhancing learning and memory, and healthy sleep has many benefits throughout the day during the developmental period. (Rolling et al., 2022). There is evidence to demonstrate a link between abnormal melatonin secretion and abnormal sleep-wake cycles. It is a fact that melatonin has several important functions for physiology, including regulation of circadian rhythm, regulation of seasonal changes, reproduction, and has antioxidant, oncostatic, anti-inflammatory and antiepileptic effects. (Marseglia et al., 2015).

In addition, childhood insomnia is a widespread problem occurring in 1-6% of the general paediatric population and in 50-75% of children with neurodevelopmental or mental comorbidities, particularly pervasive developmental disorder (including autism spectrum disorder, Asperger’s syndrome and pervasive developmental disorder) and neurogenetic disorders (Zisapel, 2018).


Melatonin or N-acetyl-5-methoxytryptamine, is a hormone, a small lipophilic substance, produced by the pineal gland and its secretion depends mainly on the levels of brightness during the day:

  • When light falls on the retina, then melatonin production is inhibited through a chain of communication, starting from the photoreceptors in the retina, through the suprachiasmatic nucleus, reaching the pineal gland.
  • When there is darkness, the suprachiasmatic nucleus sends activating warnings to the pineal gland to initiate the secretion of melatonin.

When melatonin is administered in the afternoon (at the beginning or end of the afternoon), melatonin secretion is subsequently enhanced, with the maximum effect of this phase transfer occurring when melatonin is taken 4 to 5 hours before the onset of endogenous secretion (Rolling et al., 2022).

Melatonin is administered to children and newborns for the management of many conditions, including epilepsy and neonatal sepsis. Melatonin has also been evaluated for its use as a preoperative anxiolytic and it seems that it could be preferred due to its reduced sedative effect compared to other anxiolytics. The anxiolytic function of melatonin is a consequence of its ancillary action on gamma-aminobutyric acid (GABA) transport (Mellor et al., 2022).

The use of melatonin in children is supported by numerous guidelines (Salanitro et al., 2022):

  • When sleep is disturbed, 1-3 mg of melatonin should be administered 30 min before bedtime.
  • As a chronobiotic, 0.2-0.5. mg should be administered 2-3 h before the onset of melatonin secretion that begins when light is lowest and is an indicator of the circadian phase, and increase the dose if no effect is observed.

Fresh Royal Jelly

Fresh royal jelly is a substance secreted by the glands in the hypopharynx of worker bees to feed the queen bee. It is a thick, iridescent white product with a slightly acidic taste.

Fresh royal jelly is a complete food of high nutritional value, a rich source of protein, essential amino acids, unsaturated fatty acids, natural sugars, minerals and vitamins.

Among its properties, royal jelly stands out for its nutritional, antioxidant, tonic, immunostimulating and antibacterial role.


10-HDA is a fatty acid found exclusively in royal jelly and has immunomodulatory and anti-inflammatory action.

The 10-HDA content is widely considered to be the most important parameter in quality control (1.4% is considered as a minimum in international standards (ISO 12824:2016).

Chamomile (Matricaria recutita)

Traditionally, chamomile (Matricaria recutita) has been used for centuries as an anti-inflammatory, antioxidant and healing medicine. In the form of an aqueous extract, it is often used as a mild sedative to soothe nerves and reduce anxiety, in the treatment of nightmares, insomnia and other sleep-related problems (Avallone et al., 1996) (Shinomiya et al., 2005).

Its exact mode of action is still unknown, but there is numerous evidence to suggest that one or more of the flavonoids it contains may have anxiolytic effects by affecting gamma-aminobutyric acid (GABA), noradrenaline (NA) and serotonin neurotransmission, regulating the function of the hypothalamic-pituitary-adrenal axis.

In addition, chamomile has an important effect on digestive calmness and is used to treat a variety of gastrointestinal disorders, such as flatulence, indigestion, colic, but also pseudomembranous laryngitis and fever in children (Foster et al., 1980).

Melissa officinalis L. (Melissa officinalis L.)

Melissa leaf is used in traditional medicine for its anxiolytic properties.

Although its exact mechanism of action remains unknown, many studies demonstrate that rosmarinic acid and pentacyclic triterpenoid acids act as mediators of these properties through GABA metabolism (Awad et al., 2009).

Lavender (Lavandula angustifolia Mill.)

Lavender, also known for its use in aromatherapy, has traditionally been used for its sleep aiding, anti-anxiety, anti-epileptic, analgesic, sedative and hypnotic effects (Bradley et al., 2007; Coelho et al., 2018).

Lavender helps sleep mainly by affecting the amygdala, acting on the limbic system of the brain. In addition, it improves sleep quality as it has a hypnotic effect and prevents acetylcholine secretion. The two most important constituents of lavender are linoleic acid and linalool acetate, two constituents that have shown significant hypnotic effects (Bikmoradi et al., 2015; Karadag et al., 2017; Nikfarjam et al., 2010).

Tilium (Tiliae flos)

Tilium is traditionally used to treat the common cold or to treat the symptoms of mental stress. Its muscle relaxant effect is due to the enriched alkaloids it contains, which enhance the contraction induced by acetylcholine (Hake et al., 2021).

The official monograph of herbal medicines of the European Scientific Cooperative for Herbal Medicine (ESCOP) recognizes its efficacy and safety in use by children and adults, treating psychomotor anxiety, febrile colds, cough associated with colds and upper respiratory catarrh, due to its reliable and long-term use by humans.



Helps children sleep, rest and relax

Nutritional supplement of fresh royal jelly, melatonin, melissa officinalis, chamomile, lavender and tilium

  • Helps children fall asleep*
  • Helps children relax

Composition per 10 ml:

  • Fresh royal jelly 150 mg
  • Melissa officinalis 400 mg
  • Lavender 200 mg
  • Tilium 125 mg
  • Chamomile 125 mg
  • Melatonin 1 mg

From 3 years and up: take 1 tablespoon, equivalent to 10 ml, about 30 minutes before bedtime.


FACE certification


No artificial flavors added

*Melatonin helps reduce the time it takes to fall asleep. Its beneficial effect is obtained from 1 mg of melatonin. Melatonin helps with the quality of sleep.